TRIMETHOPRIM-SULFAMETHOXAZOLE (TMP-SMX¸ BACTRIM¸S)

an antibiotic drug combination. TMP-SMX is the preferred first-line therapy for prophylaxis and treatment of PCP, and may be effective against other OI such as toxoplasmosis. Side effects include fever, nausea, diarrhea, photosensitivity, skin rash and neutropenia. Desensitization to the drug is often possible using slowly increasing dosages.