APLASTIC ANEMIA

also called Anemia Of Bone-marrow Failure, disease in which bone marrow fails to produce an adequate number of blood cells. There may be a lack of all cell types (white blood cells, red blood cells, and platelets; this form is called pancytopenia) or of one or more cell types. Rarely, the disease may be congenital (Fanconi syndrome); more commonly it is acquired by exposure to certain drugs (e.g., chloramphenicol) or non-pharmaceutical chemicals (e.g., benzene) or to ionizing radiation. About half of all cases are idiopathic (cause unknown). Aplastic anemia is most common in youth (ages 15 to 30), though it may occur at any age. Onset of the disease may be abrupt, becoming quickly severe and possibly fatal; more commonly it is insidious, running a chronic course of several years. Symptoms of chronic aplastic anemia include weakness and fatigue in the early stages, followed by shortness of breath, headache, fever, and pounding heart. There is usually a waxy pallor, and hemorrhages occur in the mucous membranes, skin, and other organs. If white blood cells (specifically, neutrophils) are lacking, resistance to infection is much lowered and infection becomes the major cause of death. When platelets are very low, bleeding may be severe. The treatment of choice for severe aplastic anemia is bone marrow transplantation, provided a compatible donor can be found. If transplantation is not practical, treatment involves avoidance of the toxic agent if known, supportive care (administration of fluids, glucose, and proteins, often intravenously), transfusions of blood components, and administration of antibiotics. Spontaneous recovery occurs occasionally.