FIBROUS DYSPLASIA

also called Mccune-Albright syndrome rare congenital developmental disorder beginning in childhood, characterized by cyst formation and replacement of solid, calcified bone with fibrous tissue, often only on one side of the body, in the long bones and pelvis. Other signs include unilateral (one-sided) enlargement of the bones of the face and base of the skull, caf au lait (pale brown) spots on the skin, and endocrine imbalance leading to precocious puberty, especially in girls. Orthopedic care may be necessary for disability resulting from pathologic fractures and bony overgrowth.