RICKETS

also called Vitamin D Deficiency, disease of infancy and childhood characterized by defective bone growth and caused by a lack of vitamin D in the body. Vitamin D is a steroid hormone that is produced in the skin by the action of sunlight's ultraviolet rays on its precursor, 7-dehydrocholesterol (provitamin D3). Vitamin D is also absorbed from the diet, especially from irradiated milk, liver, and fish oils. Vitamin D deficiency can result from a dietary deficiency, insufficient conversion in the skin by ultraviolet light, inefficient dietary absorption, or the abnormal conversion of vitamin D to its metabolites. Vitamin D is transported through the blood to its primary target tissues, the small intestine, bone, and kidney, where it helps regulate the level of calcium in those tissues. Because vitamin D plays an important role in the metabolism of calcium, in its absence, the deposition in the bones of the inorganic salt calcium phosphate (responsible for bone rigidity) does not proceed normally, and the softened bones become curved and stunted. Unless treatment is begun early, rickets may produce such conditions as bowlegs, knock-knees, and a beady appearance of the ribs (rachitic rosary) at their juncture to the breastbone. A narrowed chest and pelvis may be responsible later in life for increased susceptibility to lung diseases and difficulties in childbearing. Common early symptoms of rickets include restlessness, profuse sweating, lack of muscle tone in the limbs and abdomen, softening of the bones of the skull, delay in learning to sit, crawl, and walk, and delay in the eruption of the teeth. Tetany (spasms of the hands and feet and cramps and twitching of the muscles) may also occur. Rickets is usually effectively treated with large supplemental doses of vitamin D concentrates, with exposure to sunlight, and with a well-balanced diet. Vitamin D supplement, usually with milk, has been important in preventing the incidence of rickets in the northern and temperate climates. Recognition of the therapeutic effects of cod-liver oil and of sunlight in preventing and curing rickets in humans came in the 18th century or earlier. The existence of a vitamin responsible for the effects of cod-liver oil was indicated in experimental animals in 1918. In 1924 it was demonstrated that curative effects of ultraviolet light resulted from the formation of vitamin D by such irradiation. Pure vitamin D2 was first isolated in 193031 in England and in Germany. Two rare, closely related diseases, familial hypophosphatemia and osteomalacia (adult rickets), arise from the abnormal metabolism of phosphorus and calcium and result in the abnormal mineralization of bone and rickets-type deformities.