1. the part of Manhattan (1) in New York City which is north of 59th Street. It includes Central Park and areas on both sides of it. The Upper East Side includes the Metropolitan Museum of Art , the Guggenheim Museum and Bloomingdale’s . The Upper West Side has the Lincoln Center for the Performing Arts and Fordham University. Compare Downtown .
2. uptown n ( AmE ) the outer districts of a city or large town, where its people mostly live.
► uptown adj , adv ( AmE )
to or in the outer districts of a large city or town:
an uptown residential area
go/drive uptown