25B6; adjective
a run-down area of London : DILAPIDATED, tumbledown, ramshackle, derelict, ruinous, in ruins, crumbling; neglected, uncared-for, depressed, seedy, shabby, slummy, squalid; informal shambly; Brit. informal grotty.
she was feeling rather run down : UNWELL, ill, poorly, unhealthy, peaky; tired, drained, exhausted, fatigued, worn out, below par, washed out; Brit. off colour; informal under the weather; Brit. informal off, ropy, knackered; Scottish informal wabbit; Austral./NZ informal crook; dated seedy.