I. ˈsprü noun
Etymology: origin unknown
Date: circa 1875
1. : the waste piece on a casting (as of metal or plastic) left by the hole through which the mold was filled
2. : the hole in which a sprue forms
II. noun
Etymology: Dutch spruw; akin to Middle Low German sprūwe, a kind of tumor
Date: 1888
1. : a disease of tropical regions that is of unknown cause and is characterized by fatty diarrhea and malabsorption of nutrients — called also tropical sprue
2. : celiac disease