noun malice; malignity; spite; malicious anger; contemptuous hate.
2. despite ·noun an act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.
3. despite ·noun to vex; to annoy; to offend contemptuously.
4. despite ·prep in spite of; against, or in defiance of; notwithstanding; as, despite his prejudices.