n.
City (pop., 2000: 107,006), southern New Hampshire, U.S. Located on the Merrimack River , it is the state's largest city.
It was settled in 172223 and incorporated as the town of Derryfield in 1751. One of America's first textile mills was built there in 1805, beginning a period of rapid industrial growth. Renamed Manchester in 1810, it was incorporated as a city in 1846. Canal systems built in the early 19th century opened navigation to Boston . The textile industry's decline in the 1930s spurred industrial diversification. It is the seat of St. Anselm College, Notre Dame College, and New Hampshire College.