Any agent capable of altering a cell's genetic makeup by changing the structure of the hereditary material, DNA .
Many forms of electromagnetic radiation (e.g., cosmic rays, X rays, ultraviolet light) are mutagenic, as are various chemical compounds. The effects of some mutagens are increased or suppressed in some organisms by the presence of certain other, nonmutagenic substances; oxygen, for example, makes cells more sensitive to the mutagenic effects of X rays.