Defect in the organs or tissues of the urinary system or in the sex organs (genitals).
In polycystic kidney disease (an inherited disease), kidneys . Kidneys may have abnormal shapes or may be fused. In megaloureter, the ureter's diameter is enlarged. Males may have epispadias or hypospadias, in which the urethra opens on the upper surface or the underside, respectively, of the penis , or cryptorchidism (undescended testicles), in which one or both testes have not descended from the abdomen into the scrotum before birth. Female genital system malformations include agenesis of the ovaries , {{link=vagina">vagina , or uterus and abnormally shaped uterus.