ACTIN

protein that is an important contributor to the contractile property of muscle and other cells. It exists in two forms: G-actin (monomeric globular actin) and F-actin (polymeric fibrous actin), the form involved in muscle contraction. In muscle, two long strands of beadlike actin molecules are twisted together to form a thin filament, bundles of which alternate and interdigitate with bundles of thick filaments formed of myosin, the most abundant protein found in muscle. Two other muscle proteins, tropomyosin and troponin, regulate the temporary fusion of actin and myosin; this fusion results in the contraction of muscle. Actin and myosin have been found in dozens of other (nonmuscle) cells and are believed to be responsible for the contractile properties of animal cells generally.