BIOTIN

a water-soluble, nitrogen-containing acid essential for growth and well-being in animals and some microorganisms. Biotin functions in metabolic processes leading to the formation of fats and the utilization of carbon dioxide. A relatively stable substance, it is widely distributed in nature and is especially abundant in egg yolk, beef liver, and yeast. Biotin was first identified as a nutritive requirement of yeast. Originally called vitamin H, it was isolated in pure form in 1935; its structure was established in 1942, after it had been shown to be required by animals. Evidence for the necessity of biotin was provided by the discovery in 1927 that the addition of uncooked egg white to a diet that is otherwise adequate produces toxicity and disease. This is because egg white contains a specific protein, avidin, that combines with biotin and thus effectively prevents its action.