HODGKIN DISEASE

an uncommon cancer of the lymphatic system (malignant lymphoma) that usually strikes young adults and people 55 years of age or older. Most patients can be cured if the disease is detected in its early stages, but even those with advanced Hodgkin disease have a significant chance of recovery. The overall cure rate is approximately 75 percent. In its early stages the disease is characterized by local, painless swelling of one or more lymph nodes and sometimes by swelling of the spleen, liver, or other organs. In addition to swollen lymph nodes, symptoms may include fever and itching followed later by weight loss and fatigue. A microscopic examination of affected tissue, usually obtained from a lymph node, is required to confirm diagnosis. The cause of Hodgkin disease remains unknown, but numerous infectious agents, including bacteria, protozoa, and viruses, have been suggested. Previous infection with the Epstein-Barr virus, the causative agent of mononucleosis, has been linked to many cases of Hodgkin disease. Hodgkin disease tumours develop from B lymphocytes. Treatment consists of chemotherapy, radiation, or a combination of both, depending on the stage of development of the disease. The disease is named after Thomas Hodgkin, who first described it in 1832.