IBUPROFEN

nonsteroidal anti-inflammatory drug that is often used to treat dysmenorrhea and the symptoms of rheumatoid arthritis. Like aspirin, ibuprofen is effective against minor pain, fever, and tissue-swelling and works by inhibiting prostaglandin synthesis. (Prostaglandins are diverse and potent body chemicals that, among other effects, aid blood clotting and work to sensitize nerve endings.) Ibuprofen may irritate the gastrointestinal tract, and other ill effects may result if the drug is combined with certain other drugs. Allergy to aspirin may indicate a similar reaction to ibuprofen. The drug is not recommended for use by children under age 12, and, like aspirin and acetaminophen, it should not be used during pregnancy except under medical supervision. Ibuprofen is marketed under such trade names as Advil and Nuprin.