MUCOPOLYSACCHARIDOSIS

any of a group of genetic disorders characterized by the abnormal production, storage, and excretion of one or more mucopolysaccharides, the complex carbohydrates that are the chief constituents of the so-called ground substance, which fills the spaces between the cells and fibres of the connective tissues. These disorders cause abnormal skeletal development, mental retardation, and shortened life spans. For these disorders, all of which are classified under the mucopolysaccharidosis, or MPS, designation, see Hurler's syndrome; Hunter's syndrome; Sanfilippo's syndrome; Morquio's syndrome; Scheie's syndrome; and Maroteaux-Lamy syndrome. See also polysaccharide.