NICOTINE

an organic compound that is the principal alkaloid of tobacco. (An alkaloid is one of a group of nitrogenous organic compounds that have marked physiological effects on humans.) Nicotine occurs throughout the tobacco plant and especially in the leaves. The compound constitutes about 5 percent of the plant by weight. Both the tobacco plant (Nicotiana tabacum) and the compound are named for Jean Nicot, a French ambassador to Portugal, who sent tobacco seeds to Paris in 1550. Crude nicotine was known by 1571, and the compound was obtained in purified form in 1828; the correct molecular formula was established in 1843, and the first laboratory synthesis was reported in 1904. Nicotine is one of the few liquid alkaloids. In its pure state it is a colourless, odourless liquid with an oily consistency, but when exposed to light or air, it acquires a brown colour and gives off a strong odour of tobacco. Nicotine's chemical formula is C10H14N2. Nicotine is the chief addictive ingredient in the tobacco used in cigarettes, cigars, and snuff. In its psychoactive effects, nicotine is a unique substance with a biphasic effect; when inhaled in short puffs it has a stimulant effect, but when smoked in deep drags it can have a tranquilizing effect. This is why smoking can feel invigorating at some times and can seem to block stressful stimuli at others. Nicotine is also an addictive drug, though, and smokers characteristically display a strong tendency to relapse after having successfully stopped smoking for a time. When ingested in larger doses, nicotine is a highly toxic poison that causes vomiting and nausea, headaches, stomach pains, and, in severe cases, convulsions, paralysis, and death. Nicotine is commercially obtained from tobacco scraps and is used as an insecticide and as a veterinary vermifuge. Nitric acid or other oxidizing agents convert it to nicotinic acid, or niacin, which is used as a food supplement.