VAGINA

canal in female mammals that receives the male reproductive cells, or sperm, and is part of the birth canal during the birth process. In humans, it also functions as an excretory canal for the products of menstruation. In humans the vagina is about 9 cm (3.5 inches) long; it is located in front of the rectum and behind the bladder. The cervix of the uterus connects to the upper region of the vagina. The vaginal channel is narrowest at the upper and lower ends. In most virgins, the external opening to the vagina is partially closed by a thin fold of tissue known as the hymen. The opening (vaginal orifice) is partially covered by the labia majora. The lining of the vaginal cavity responds to stimulation from the various ovarian hormones by either building new cell layers or shedding the old ones. The thickness of the lining varies directly with the amount of estrogen liberated from the ovaries; the lining is thickest and most elastic during ovulation (egg release from the ovaries) and during pregnancy. The vaginal lining characteristically has several transverse ridges known as vaginal rugae, which permit expansion of the vaginal cavity. These tend to disappear in older women and in those women who have borne children. There are no glands in the vaginal wall. The mucus that lubricates the vaginal cavity had traditionally been ascribed to the cervix or to the Bartholin's glands in the labia. After extensive clinical observation, however, William H. Masters and Virginia Johnson reported in 1966 that vaginal lubrication during sexual excitement was supplied by the seepage of a mucuslike fluid through the walls of the vagina. The cells in the lining contain large quantities of glycogen (stored animal starch). Bacteria within the vagina ferment the glycogen, so that lactic acid is produced. The lactic acid makes the surface of the lining slightly acidic, thus protecting against disease-causing microorganisms that have gained entry via the vaginal orifice. The muscle walls of the vagina are thick and elastic in order to accommodate both the movement of the penis during intercourse and the passage of a child during delivery. The muscular wall is composed of two layers of muscle fibres, a weak internal circular layer and a strong external longitudinal layer. Covering the muscle tissue is a sheath of connective tissue that consists of blood vessels, lymphatic ducts, and nerve fibres. This layer joins those of the urinary bladder, rectum, and other pelvic structures. Maladies that can affect the vagina include bacterial infections (see leukorrhea; vaginitis), ulcerated sores, prolapse (in which the internal portions of the vagina protrude out of the vaginal orifice), and occasionally cancerous tumours.