up [informal] - bored, annoyed or disappointed, esp. by something that you have experienced for too longTiffany says she's totally fed up - she's going to give up this awful job and move back to New York.Are you fed up about not getting the job?(esp. UK and ANZ) I'm fed up to the back teeth (= very fed up) with/of being criticized by people who know nothing about my work.
FED
Meaning of FED in English
Cambridge English vocab. Кембриджский английский словарь. 2012