1.
If you are ~ with something, it causes you a lot of worry or hard work.
Nicaragua was ~ with a foreign debt of $11 billion...
They may be ~ by guilt and regret.
ADJ: v-link ADJ with/by n
2.
If you describe someone as ~ with a heavy load, you are emphasizing that it is very heavy and that they are holding it or carrying it with difficulty.
Anna and Rosemary arrived ~ by bags and food baskets.
ADJ: v-link ADJ with/by n emphasis