ANODYNE Meaning of ANODYNE in English adj. & n.adj. 1 able to relieve pain. 2 mentally soothing. n. an anodyne drug or medicine. [ L anodynus f. Gk anodunos painless (as AN-(1), odune pain) ] Concise Oxford English dictionary. Краткий оксфордский словарь английского языка. 2012