LESION Meaning of LESION in English [ 'li:ʒ(ə)n ]■ noun chiefly Medicine a region in an organ or tissue which has suffered damage through injury or disease.OriginME: via OFr. from L. laesio(n-) , from laedere 'injure'. Concise Oxford English vocab. Сжатый оксфордский словарь английского языка. 2004