POTENTIATE Meaning of POTENTIATE in English [ pə(ʊ)'tɛnʃɪeɪt ]■ verb increase the power or effect of (something such as a drug or physiological reaction).OriginC19: from potent 1 , on the pattern of substantiate . Concise Oxford English vocab. Сжатый оксфордский словарь английского языка. 2004