WISEACRE Meaning of WISEACRE in English [ 'wʌɪzeɪkə ]■ noun a person with an affectation of wisdom or knowledge.OriginC16: from MDu. wijsseggher 'soothsayer', prob. from the Gmc base of wit 2 . Concise Oxford English vocab. Сжатый оксфордский словарь английского языка. 2004