CFC Meaning of CFC in English CFC /ˌsiː ef ˈsiː/ BrE AmE noun [countable] (chlorofluorocarbon) a gas used in ↑ fridge s and ↑ aerosol cans, believed to be responsible for damaging the ↑ ozone layer Longman Dictionary of Contemporary English. Longman - Словарь современного английского языка. 2012