un ‧ res ‧ pon ‧ sive AC /ˌunrɪˈspɒnsɪv $ -rɪˈspɑːn-/ BrE AmE adjective
[ Word Family: noun : ↑ respondent , ↑ response , ↑ responsiveness ; verb : ↑ respond ; adverb : ↑ responsively ; adjective : ↑ responsive ≠ ↑ unresponsive ]
not reacting to something or not affected by it
unresponsive to
The disease is totally unresponsive to conventional treatment.
His warning fell on unresponsive ears (=was not listened to) .