PYODERMA GANGRENOSUM

An ulcerating condition of skin resulting in heaped borders with a typical appearance. Pyoderma gangrenosum appears to be mediated by the immune system, but the exact cause is unknown. The lesion(s) usually begin as a soft nodule on the skin which proceeds to ulcerate. The ulcer enlarges and the skin at the edge is purple-red. Ulcers can become quite large. This condition is associated with several other diseases, some of which are ulcerative colitis, Crohn’s disease, rheumatoid arthritis, leukemia, and cryoglobulinemia. Pyoderma gangrenosum is usually responsive to corticosteroids.