ANTIDEPRESSANT Meaning of ANTIDEPRESSANT in English [an.ti.de.pres.sant] adj (1961): used or tending to relieve or prevent psychic depression [2]antidepressant n (1962): an antidepressant drug--compare tricyclic antidepressant Merriam-Webster English vocab. Английский словарь Merriam Webster. 2012