DEPOPULATE Meaning of DEPOPULATE in English [de.pop.u.late] vt [L depopulatus, pp. of depopulari, fr. de- + populari to ravage] (1548) 1 obs: ravage 2: to reduce greatly the population of -- de.pop.u.la.tion n Merriam-Webster English vocab. Английский словарь Merriam Webster. 2012