MEGALOPOLIS Meaning of MEGALOPOLIS in English [meg.a.lop.o.lis] n (ca. 1828) 1: a very large city 2: a thickly populated region centering in a metropolis or embracing several metropolises -- meg.a.lo.pol.i.tan n or adj Merriam-Webster English vocab. Английский словарь Merriam Webster. 2012