PEYOTE Meaning of PEYOTE in English [pey.o.te] also pey.otl n [MexSp peyote, fr. Nahuatl peyotl] (1849) 1: a stimulant drug derived from mescal buttons 2: any of several American cacti (genus Lophophora); esp: mescal Merriam-Webster English vocab. Английский словарь Merriam Webster. 2012