Synonyms and related words :
aching heart, affliction, agonizingness, agony, anguish, bale, bleeding heart, broken heart, brokenheartedness, care, desolateness, desolation, dole, excruciatingness, excruciation, grief, heartache, heartbrokenness, heartsickness, heartsoreness, regret, rue, torment, tormentingness, torture, torturousness, woe