ˈ ̷ ̷ ˌ ̷ ̷ ̷ ̷ ˌ ̷ ̷ ̷ ̷ noun
Etymology: down + regulation (IV)
: the process of reducing or suppressing a response to a stimulus ; specifically : reduction in a cellular response to a molecule (as of insulin) from a decrease in the number of receptors on the cell surface
• downregulate transitive verb