ə̇ˈstrānjmənt, eˈ- noun
( -s )
: the act of estranging or the condition of being estranged : alienation especially in friendship
the small difference of opinion snowballed into mutual resentment and resulted in final and total estrangement
the hero, a middle-aged intellectual and student, has passed through successive estrangements from bourgeois life — Time
resulted in the almost complete estrangement of arts and letters from the sciences — Scientific American Reader