MISSIS Meaning of MISSIS in English /mis"iz, -is/ , n.1. Older Use. wife: I'll have to ask the missis.2. the mistress of a household. Also, missus . [ 1780-90; var. of MISTRESS ] Random House Webster's Unabridged English dictionary. Полный английский словарь Вебстер - Random House . 2012