(April 3, 1559) Agreement marking the end of the 65-year struggle (1494–1559) between France and Spain for the control of Italy.
France gave up its claims to Italian territory, leaving Habsburg Spain the dominant power there. France returned Savoy and Piedmont to Spain's ally Emmanuel-Philibert of Savoy (1528–80) and restored Corsica to Genoa. Elsewhere, France retained Calais, which it had seized from England in 1558, and the bishoprics of Toul, Metz, and Verdun, taken from Emperor Charles V .