City (pop., 2000: 173,890), eastern Tennessee, U.S. In 1785 a treaty with the Cherokee Indians opened the region to settlers, and Capt.
James White established a frontier outpost called White's Fort. In 1791 it was renamed Knoxville for American Civil War , it was occupied by the Confederates until 1863. It is the seat of the University of Tennessee and Knoxville College as well as the headquarters of the {{link=Tennessee Valley Authority">Tennessee Valley Authority .