BURKITT, DENIS PARSONS

born Feb. 28, 1911, Enniskillen, N.Ire. died March 23, 1993, England British surgeon and medical researcher. Burkitt graduated from Trinity College, Dublin, in 1933 and earned his medical degree there in 1946 after serving as a doctor in the British army during World War II. In 1946 he joined the British colonial service in Uganda, where he was a government surgeon. In 1957 Burkitt became interested in a lethal cancer of the lymphatic system with a high incidence among children. After a wide-ranging study of hospital and physicians' records across the continent, he was able to demonstrate that Burkitt's lymphoma (as it is now known) commonly occurs only in mosquito-ridden parts of equatorial Africa, in regions where malaria and yellow fever are also endemic. This research suggested that some insect vector was the carrier of an infectious agent responsible for the disease. Burkitt's research led to the discovery that the lymphoma is linked to the presence of the Epstein-Barr virus (the cause of acute infectious mononucleosis) in children whose immune system is depressed by chronic malaria. Burkitt later helped develop an effective chemotherapy treatment for the lymphoma. Aside from his work in tropical medicine, Burkitt was best known to the general public for his theory that a high-fibre diet helps protect against colon cancer and other diseases. His book Don't Forget Fibre in Your Diet (1979) helped trigger public interest in maintaining adequate levels of fibre in daily nutrition.