HITCHINGS, GEORGE HERBERT

born April 18, 1905, Hoquiam, Wash., U.S. died Feb. 27, 1998, Chapel Hill, N.C. American pharmacologist who, along with Gertrude B. Elion and Sir James W. Black, received the Nobel Prize for Physiology or Medicine in 1988 for their development of drugs that became essential in the treatment of several major diseases. Hitchings received his bachelor's and master's degrees from the University of Washington and earned a Ph.D. in biochemistry at Harvard University in 1933. He taught at Harvard until 1939, and in 1942 he joined the Burroughs Wellcome Laboratories, at which he conducted research until his retirement in 1975. Over a span of nearly 40 years, Hitchings worked with Elion, who was first his assistant and then his colleague in research at Burroughs Wellcome. Together they designed a variety of new drugs that achieved their effects by interfering with the replication or other vital functions of specific pathogens (disease-causing agents). In the 1950s they developed thioguanine and 6-mercaptopurine (6MP), which became important treatments for leukemia. In 1957 their alteration of 6MP produced the compound azathioprine, which proved useful in treating severe rheumatoid arthritis and other autoimmune disorders and in suppressing the body's rejection of transplanted organs. Their new drug allopurinol was an effective treatment for gout. Other important drugs that were developed by Hitchings and Elion include pyrimethamine, an antimalarial agent; trimethoprim, a treatment for urinary-tract and other bacterial infections; and acyclovir, the first effective treatment for viral herpes.