MARIE, PIERRE

born Sept. 9, 1853, Paris died April 13, 1940, Paris French neurologist whose discovery that growth disorders are caused by pituitary disease contributed to the modern science of endocrinology. A student of the neurologist Jean Charcot at the Salptrire Hospital, Paris (1885), Marie published the first description of acromegaly (1886), a condition characterized by overgrowth of bone tissue such as that of the nose, jaws, fingers, and toes, and traced the disease to a tumour of the pituitary gland, at the base of the brain. He first described pulmonary osteoarthropathy (1890; inflammation of the bones and joints of the four limbs, often secondary to chronic conditions of the lungs and heart); hereditary cerebellar ataxia, also known as Marie's ataxia (1893; a disease in young adults characterized by a failure of muscular coordination caused by an atrophy of the cerebellum); and (with Charcot) a type of progressive muscular atrophy known as the CharcotMarie type. He served as professor of neurology at the University of Paris from 1907 to 1925.