SEPARATION AND PURIFICATION

in chemistry, separation of a substance into its components and the removal of impurities. There are a large number of important applications in fields such as medicine and manufacturing. Additional reading Broad coverage of the field is provided in Barry L. Karger, Lloyd R. Snyder, and Csaba Horvth, An Introduction to Separation Science (1973), a modern treatment of theory and practice, with emphasis on small-scale operation; J. Calvin Giddings, Unified Separation Science (1991), a fundamental text on the principles of separation methods; and C. Judson King, Separation Processes, 2nd ed. (1980), a fundamental text dealing with large-scale engineering and separation procedures. Anthony T. Andrews, Electrophoresis: Theory, Techniques, and Biochemical and Clinical Applications, 2nd ed. (1986), introduces this method. Advances in Electrophoresis (annual) reviews the literature. Useful journals include Separation Science and Technology (monthly); and Electrophoresis (monthly). Barry L. Karger