SERUM ALBUMIN

protein that accounts for 55 percent of the total protein in blood plasma. Its major function is to help maintain the osmotic pressure between the blood vessels and tissues. Circulating blood tends to force fluid out of the blood vessels and into the tissues, where it results in edema (swelling from excess fluid). The colloid nature of albumin and, to a lesser extent, of other blood proteins called globulins, keeps the fluid within the blood vessels. Albumin also contains two materials necessary for the control of blood clotting: (1) antithrombin, which keeps the clotting enzyme thrombin from working unless needed, and (2) heparin cofactor, which is necessary for the anticlotting action of the acid heparin. The albumin level falls and rises in such liver disorders as cirrhosis or viral hepatitis. Transfusions of albumin are used to combat shock and whenever it is necessary to remove excess fluid from the tissues. Similar albumin compounds with other functions occur in plants, animal tissues, egg whites, and milk.