SCREW

up [phrasal verb] [I or M; C] [informal] - to cause (something) to fail or be spoiled, or to cause (someone) to become anxious and unhappyI reckon I've passed the physics exam, but I'm sure I screwed chemistry up. [M]Having the car stolen completely screwed up our holiday plans. [M]We really screwed up when we invited Jane and two of her ex-boyfriends to the party. [I]It really screwed him up when he saw his friend get killed. [M]