MADONNA Meaning of MADONNA in English ■ noun ( the ~ ) the Virgin Mary.OriginC16 (as a respectful form of address for an Ital. woman): Ital., from ma (old form of mia 'my') + donna 'lady' (from L. domina ). Concise Oxford English vocab. Сжатый оксфордский словарь английского языка. 2004