[ vɪ'sɪsɪtju:d , vʌɪ- ]
■ noun
1》 a change of circumstances or fortune, typically for the worse.
2》 literary alternation between contrasting things.
Derivatives
vicissitudinous -'tju:dɪnəs adjective
Origin
C17: from Fr., or from L. vicissitudo , from vicissim 'by turns', from vic- 'turn, change'.