VICISSITUDE

noun see: week Date: circa 1576 1. the quality or state of being changeable ; mutability, natural change or mutation visible in nature or in human affairs, 2. a favorable or unfavorable event or situation that occurs by chance ; a fluctuation of state or condition , a difficulty or hardship attendant on a way of life, a career, or a course of action and usually beyond one's control, alternating change ; succession