noun
COLLOCATIONS FROM CORPUS
■ NOUN
alfa
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Tumour necrosis factor, interferon alfa , and interleukin 2 have already been expressed and secreted in high concentrations within certain tumours.
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We report on patients with chronic viral hepatitis who died of hepatic decompensation during or shortly after interferon alfa treatment.
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These centres had treated 2490 patients with chronic viral hepatitis with interferon alfa .
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No apparent reason for the liver failure other than interferon alfa treatment could be detected in any of the patients.
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A relation between liver failure and interferon alfa seems probable in the patients who did not have hepatic decompensation before treatment.
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Most of the patients developed ascites, jaundice, and encephalopathy that progressed even after interferon alfa was stopped.
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There are several possible explanations for a link between interferon alfa and fatal hepatic injury.
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Other possible explanations are that interferon alfa is directly toxic to hepatocytes and that it induces autoimmune chronic active hepatitis.
EXAMPLES FROM CORPUS
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All but one patient exhibited the response while on interferon therapy.
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For the time being however, interferon remains very much an experimental drug whose full clinical value has yet to be determined.
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Now, it seems, interferon is less than perfect.
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Trials of interferon in viral disease have certainly met with some success.
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Tumour necrosis factor, interferon alfa, and interleukin 2 have already been expressed and secreted in high concentrations within certain tumours.
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Usually interferon is given in a single continuous course.
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We report on patients with chronic viral hepatitis who died of hepatic decompensation during or shortly after interferon alfa treatment.