TITICACA Meaning of TITICACA in English Tit ‧ i ‧ ca ‧ ca, Lake /ˌtɪtɪˈkɑːkə/ BrE AmE the largest lake in South America, and the highest in the world, in the ↑ Andes mountains between Bolivia and Peru Longman Dictionary of Contemporary English. Longman - Словарь современного английского языка. 2012