DIARRHEA, ANTIBIOTIC-INDUCED

A bacterium called Clostridium difficile (C.difficile), one of the most common causes of infection of the large bowel (colon). Patients taking antibiotics are at particular risk of becoming infected with C. difficile. Antibiotics disrupt the normal bacteria of the bowel, allowing C. difficile bacteria (and other bacteria) to become established and overgrow the colon. Many persons infected with C. difficile bacteria have no symptoms but can become carriers of the bacteria and infect others. In other people, a toxin produced by C. difficile causes diarrhea, abdominal pain, severe inflammation of the colon (colitis), fever, an elevated white blood count, vomiting and dehydration. In severely affected patients, the inner lining of the colon becomes severely inflamed (a condition called pseudomembranous colitis). Rarely, the walls of the colon wear away and holes develop (colon perforation), which can lead to a life-threatening infection of the abdomen.