Synonyms and related words :
abnormality, acute disease, adverse circumstances, adversity, affection, aggravation, ailment, allergic disease, allergy, anguish, annoyance, atrophy, bacterial disease, bane, birth defect, bitter cup, bitter draft, bitter draught, bitter pill, blight, bugbear, bummer, burden, burden of care, calamity, calvary, cankerworm of care, cardiovascular disease, care, catastrophe, chronic disease, circulatory disease, complaint, complication, condition, congenital defect, cross, crown of thorns, crucible, crushing burden, curse, death, defect, deficiency disease, deformity, degenerative disease, destruction, difficulties, difficulty, disability, disaster, disease, disorder, distemper, distress, dole, downer, encumbrance, endemic, endemic disease, endocrine disease, epidemic disease, evil, functional disease, fungus disease, gall, gall and wormwood, gastrointestinal disease, genetic disease, grief, grievance, handicap, hard knocks, hard life, hard lot, hardcase, hardship, harm, heartache, heartbreak, hereditary disease, iatrogenic disease, illness, indisposition, infectious disease, infirmity, infliction, irritation, load, malady, malaise, mischance, misery, misfortune, mishap, morbidity, morbus, muscular disease, nemesis, neurological disease, nutritional disease, occupational disease, open wound, oppression, ordeal, organic disease, pack of troubles, pain, pandemic disease, pathological condition, pathology, peck of troubles, pest, pestilence, plague, plant disease, plight, predicament, pressure, protozoan disease, psychosomatic disease, regret, respiratory disease, rigor, rockiness, rue, running sore, scourge, sea of troubles, secondary disease, seediness, sickishness, sickness, signs, sorrow, stress, stress of life, suffering, symptomatology, symptomology, symptoms, syndrome, the pip, thorn, torment, trial, tribulation, trouble, troubles, urogenital disease, vale of tears, vexation, vicissitude, virus disease, visitation, wasting disease, waters of bitterness, weight, woe, worm disease, wretchedness